Overview
The Department of Biochemistry, ICMR-NIRT is playing an important role in the clinical management of study participants involved in various clinical trials and contributing exemplarily to the basic research involving Drug delivery approaches, point of care diagnosis and nutritional intervention etc. The National Accreditation Board for Testing and Calibration laboratories (NABL) accredited clinical chemistry unit of the laboratory fulfils the prime mandate of the institute by providing high quality diagnostic and research support to various research projects conducted at ICMR-NIRT.
Head of the Department:
Dr. N Saravanan, M.Sc., M.Phil., Ph.D., Scientist 'E'
Email id :
natrajan[dot]s[at]icmr[dot]gov[dot]in
| Sr. No. | Name of the Staff | Designation |
|---|---|---|
| 1 | Dr. Saravanan N | Scientist E |
| 2 | Dr. Souparnika S | Scientist C |
| 3 | Mr. Rajakumar S | Technical Officer-C |
| 4 | Mr. Ananda Kumar B | Technical Officer-B |
| 5 | Mr. Sanjay Kumar Pal | Technical Assistant |
| 6 | Ms. Vidhi | Technical Assistant |
| 7 | Mr. Santhana Mahalingam | Technician (2) |
| 8 | Mr. Ravichandran R | Lab Assistant |
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Key areas of research
Drug delivery approaches in tuberculosis treatment
Point of care diagnostic tools
Biomarker identification using metabolomics
Nutrition and functional foods in tuberculosis treatment
List of ongoing projects
Point of care estimation of Vitamin D and C - reactive protein for tuberculosis screening in household contacts of active pulmonary tuberculosis patients in Tamil Nadu, India.
Assessment of Intestinal barrier integrity in Tuberculosis and its association with anti-TB drug levels
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NABL accredited Clinical Biochemistry Laboratory facility that cater the research and diagnostic requirements of the Institute.
The Clinical Chemistry Analyzer is integrated with Laboratory Information Management System for the rapid dissemination of test reports.
The Metabolomics facility is established with LCMSMS for biomarker discovery and lead molecule identification, drug estimation, nutrient estimation etc.
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Nagarajan U, Naha A, Ashok G, Balasubramanian A, Ramaiah S, V Kanth S, Dusthackeer A, Anbarasu A, Natarajan Saravanan. Biomolecular Interaction of Carnosine and Anti-TB Drug: Preparation of Functional Biopeptide-Based Nanocomposites and Characterization through In Vitro and In Silico Investigations. ACS omega. 2024 Dec 25;10(1):567-87.
Silambu Chelvi Kannayan, Basilea Watson, Kannan Thiruvengadam, Ghazala Shamail, Banurekha Velayutham, Rajendran Krishnan, Saravanan Natarajan. Malnutrition in tribal people living with tuberculosis in India: A systematic review & meta-analysis. The Indian Journal of Medical Research. 2024 Sep 30;160(1):23.
Nagarajan U, Denise RM, Kanth SV, Natarajan Saravanan. An eco friendly approach for the development of a dipeptide based anti-TB drug nanocomposites: A greener approach in drug delivery system for pulmonary delivery. Sustainable Materials and Technologies. 2024 Jul 3:e01037.
Usharani N, Aniket N, Anand A, Sudha R, Swarna V. K, Saravanan N. Green synthesis and characterization of water soluble nanocarnosine: A prospective drug delivery system. Appl. Mater. Today. 2023; 32: 101812.
Souparnika Sreelatha, Usharani N, Saravanan Natarajan. Protein targets in Mycobacterium tuberculosis and their inhibitors for therapeutic implications: A narrative review. Int. J. Biol. Macromol Volume 243:2023, 125022
Usharani N, Kanth SV, Saravanan N. Current nanotechnological strategies using lipids, carbohydrates, proteins and metal conjugates-based carrier systems for diagnosis and treatment of tuberculosis-A review. Int. J. Biol. Macromol. 2022;S0141-8130.
Miryala SK, Basu S, Naha A, Debroy R, Ramaiah S, Anbarasu A, Natarajan Saravanan. Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: a molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids. 2021 Nov 1;341:117340.
Ahmed NZ, Agibothu Kupparam HK, Akbar S, Hissar S, Anwar N, Thiruvengadam K, Anjum N, Khan AA, Dar S, Natarajan Saravanan. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats. Journal of Complementary and Integrative Medicine. 2021 Sep 30;18(3):517-25.
Rupak Shivakoti, John W Newman, Luke Elizabeth Hanna, Artur TL Queiroz, Kamil Borkowski, Akshay N Gupte, Mandar Paradkar, Pattabiraman Satyamurthi, Vandana Kulkarni, Murugesh Selva, Neeta Pradhan, Shri Vijay Bala Yogendra Shivakumar, Saravanan Natarajan, Ramesh Karunaianantham, Nikhil Gupte, Kannan Thiruvengadam, Oliver Fiehn, Renu Bharadwaj, Anju Kagal, Sanjay Gaikwad, Shashikala Sangle, Jonathan E Golub, Bruno B Andrade, Vidya Mave, Amita Gupta, Chandrasekaran Padmapriyadarsini. Host lipidome and tuberculosis treatment failure. European Respiratory Journal. 2022 Jan 6;59(1).
Chandrasekaran P, Saravanan N, Bethunaickan R, Tripathy S. Malnutrition: Modulator of immune responses in tuberculosis. Front.Immunol. 2017 ; 8:1316
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The Department of Biochemistry, ICMR-NIRT is actively contributing to the National TB Elimination Programme by providing high quality clinical chemistry and diagnostic support to various clinical trials and experimental studies conducted by institutional scientists.
The members of the department have actively participated in various government initiatives such as International Women's Day, National Sports Day and Vigilance Awareness Week etc.
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