Ongoing Studies

LIST OF ONGOING STUDIES AS ON 12th FEBRUARY, 2024

Pharmacokinetic drug-drug interactions between first line anti-TB and anti-diabetic drugs

Dr. A.K. Hemanth Kumar

Pharmacokinetics of second-line anti-TB drugs in children and adolescents with MDR TB

Dr. A.K. Hemanth Kumar

Bioavailability of fixed dose combination of first line anti-TB drugs in patients with pulmonary tuberculosis

Dr. A.K. Hemanth Kumar

Molecular cloning and characterization of full-length infectious Transmitted/Founder HIV-1 viruses

Dr. Luke E. Hanna

Identification of broadly neutralizing antibodies against HIV

Dr. Luke E. Hanna

Inflammation and aging in HIV-infected individuals on long-term antiretroviral therapy

Dr. Luke E. Hanna

Identification of biomarkers that can predict progression from Latent Tuberculosis Infection to active TB disease

Dr. Luke E. Hanna

National HIV Cohort Program – Cohorts of HIV Resistance and Progression in Indian Children and Adults (CoHRPICA)

Dr. Luke E. Hanna

Impact of malnutrition on immune responses to tuberculosis in Indian children

Dr. Aishwarya Venkataraman

Development and validation of a diagnostic kit for early detection of Human Papilloma Virus (HPV) infection in cervical cancer

Dr. N. Sudhakar

Latent class analysis of health-related quality of life of TB patients during & post-treatment in a Longitudinal Design

Dr. M. Vasantha

Development of a Database of Clinical Study X-rays at ICMR-NIRT, Chennai

Dr. C. Ponnuraja

HTA for implementation of cell counters for referral of suspected dengue cases at PHC settings

Dr. M. Muniyandi

The Economic evaluation of standardised treatment regimens of anti-TB drugs for patients with MDR-TB (STREAM stage-II trial)

Dr. M. Muniyandi

Social network analysis as a tool to improve active case finding at the community level in Chennai

Dr. N. Karikalan

Measuring the socio-economic risk-benefits & health-related quality of life changes associated with TB disease disclosure

Dr. N. Karikalan

Early bactericidal activity of anti-tuberculosis drugs

Dr. K.R. Uma Devi

Protecting and improving public health globally: Building laboratory, surveillance, and workforce capacity to detect, respond to, and prevent drug-resistant tuberculosis in India

Dr. K.R. Uma Devi

Identification of the latent tuberculosis-specific marker by the immunoproteomic analysis of the cell wall and membrane proteins of M. tuberculosis

Dr. K.R. Uma Devi

Accurate, Rapid, Robust, and Economical diagnostic technologies for Tuberculosis: ARREST-TB

Dr. K.R. Uma Devi

Crohn's disease in India: A multicenter study from a country where intestinal tuberculosis as well as Johne’s disease is endemic

Dr. P. Kannan

Studies on epigenome-wide alterations in alveolar macrophages during M. tuberculosis infections in a guinea pig pulmonary tuberculosis model

Dr. P. Kannan

Whole Genome Sequencing and Transcriptome analysis of M. tuberculosis clinical isolates from Bovine and Human Origin

Dr. P. Kannan

Identification of Mycobacterium tuberculosis complex (MTBC) organisms in the lymph node samples of slaughtered cattle in Chennai

Dr. P. Kannan

Dereplication-guided bio-prospecting of cyclic lipopeptides from marine Bacillus sp. for inhibition of M. tuberculosis

Dr. P. Kannan

Mentor for the project

Dr. Sagarika Devi (PI for the project)

Systems biology and immunology of the effect of tuberculosis chemoprophylaxis in HIV infection

Dr. Syed Hissar & Dr. Pavan Kumar

An open-label, three-arm, pragmatic, randomized controlled pilot study to determine the protective effect of Kabha Sura Kudineer (KSK)/ Nilavembu Kudineer (NVK) in preventing COVID-19 symptoms compared to standard Vitamin C-Zinc supplementation and to examine immune responses among healthcare workers

Dr. Pavan Kumar & Dr. Subash Babu

Identification of tuberculosis-specific biomarkers in children by the proteomic analysis of urine

Dr. D. Anbarasu & Dr. Syed Hissar

Molecular Analysis of monocyte subsets in humans infected with Mycobacterium tuberculosis

Dr. Ramalingam B

Attenuated mycobacteria-based vaccine against tuberculosis with a novel strategy for T cell priming

Dr. K.R. Uma Devi

CRISPR-mediated platform for diagnosis and rapid detection of drug resistance pattern in M. tuberculosis

Dr. K.R. Uma Devi

Functional characterization of oxidoreductases of M. tuberculosis

Dr. P. Kannan

Study on mutations associated with Pyrazinamide resistance in M. tuberculosis

Dr. P. Kannan

A cross-sectional study of the systems immunology and viral diversity of SARS-CoV-2 infection, COVID-19 disease, and Multisystem Inflammatory Syndrome in children

Dr. Pavan Kumar & Dr. Subash Babu

Characterization and durability of COVID-19 vaccine-induced immune responses in healthcare/frontline workers

Dr. Pavan Kumar & Dr. Banu Rekha

Humoral and cellular immune response among recovered COVID-19 patients: A cross-sectional study, Tiruvallur district, Chennai Corporation, Tamil Nadu, India, 2020

Dr. Pavan Kumar (Co-PI)

Role of neutralizing antibodies and inflammatory biomarkers in children with Paediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS)

Dr. Pavan Kumar (Co-PI)

Regional Prospective Observational Research in Tuberculosis (RePORT) - Phase 2

Dr. Pavan Kumar (Co-PI)

CYP2R1 gene polymorphisms in pulmonary tuberculosis

Dr. Ramalingam B & Dr. Harishanker

Immunomodulation of Autophagy by Vitamin D3 in macrophages infected with Mycobacterium tuberculosis

Dr. Ramalingam B

Molecular and immune profiling in adults affected with COVID-19 disease

Dr. N. Sudhakar

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