Overview
The primary mandate is to carry out research in understanding the pharmacokinetics (PK) of anti-tuberculosis (anti-TB) drugs, their variability and factors associated with pharmacokinetic variability in humans. The department provides service and support to therapeutic drug monitoring (TDM) of anti-TB drugs of patients undergoing treatment for TB disease management. In addition, we develop and validate newer and simpler HPLC methods for measuring anti-TB, anti-viral and anti-diabetic drugs in different biological specimens, such as plasma/serum, urine and saliva.
Head of the Department:
Dr. S.M. Jeyakumar, M.Sc., M.Phil., Ph.D., Scientist 'F'
Email id :
jeyakumar[dot]sm[at]icmr[dot]gov[dot]in
| Sr. No. | Name of the Staff | Designation |
|---|---|---|
| 1 | Dr. Jeyakumar S.M | Scientist F |
| 2 | Mr. Karmveer Yadav | Technical Officer-B |
| 3 | Mr. Mangalampalli Manikantha Anikumar | Technical Assistant |
| 4 | Mr. Muni Nagesh | Technical Assistant |
| 5 | Ms. Sudha V | Senior Technician (1) |
| 6 | Mr. Kawaskar M | Technician (2) |
| 7 | Mr. Vijayakumar A | Technician (2) |
| 8 | Mr. Thamizharasan V | Lab Attendant -1 |
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Research focuses:
Pharmacokinetics of anti-TB drugs
Drug metabolism and Nutrition
Development of new methods for measuring anti-TB drugs using HPLC
Ongoing projects:
Bioavailability of first-line anti-TB drugs among patients receiving fixed-dose combination (FDC) tablets.
Pharmacokinetics of linezolid in MDR-TB patients.
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High-performance liquid chromatography (HPLC)
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Rebecca Yowaraj M, Vilvamani S, Bharathiraja T, et al. Pharmacokinetic drug-drug interaction between first-line anti-TB and anti-diabetic drugs in patients with tuberculosis and diabetes mellitus. Indian J Tuberc. 2025;72 Suppl 1:S43-S49. doi:10.1016/j.ijtb.2024.10.009
Agibothu Kupparam HK, Shah I, Chandrasekaran P, et al. Pharmacokinetics of anti-TB drugs in children and adolescents with drug-resistant TB: a multicentre observational study from India. J Antimicrob Chemother. 2024;79(11):2939-2947. doi:10.1093/jac/dkae311
Vilvamani S, Mahalingam S, Nhavilthodi S, Murugesan D, Jeyakumar SM. Development and Validation of a Simple High-Pressure Liquid Chromatography-Ultraviolet Detection Method for Simultaneous Quantitation of First-Line Anti-Tuberculosis Drugs in Formulations of Fixed-Dose Combination. J Chromatogr Sci. 2024;62(9):821-828. doi:10.1093/chromsci/bmae023
Singla R, Gupta A, Kumar V, et al. Study of risk factors and clinical management of patients with clinical non-response due to low plasma levels of anti-tubercular drugs. Monaldi Arch Chest Dis. Published online July 23, 2024. doi:10.4081/monaldi.2024.3036
Jeyakumar SM, Bhui NK, Singla N, et al. Long-Term Intake of Linezolid Elevates Drug Exposure and Reduces Drug Clearance and Elimination in Adults With Drug-Resistant Pulmonary Tuberculosis. Ther Drug Monit. 2023;45(6):754-759. doi:10.1097/FTD.0000000000001111
Ramachandran G, Hemanth Kumar AK, Kannan T, Thangakunam B, Shankar D, Christopher DJ. Pharmacokinetics of rifampicin, isoniazid & pyrazinamide during daily & intermittent dosing: A preliminary study. Indian J Med Res. 2023;157(2&3):211-215. doi:10.4103/ijmr.IJMR_1835_19
Mary Rebecca Y, Sudha V, Bharathiraja T, Kannan T, Lavanya J, Hemanth Kumar AK. Urinary excretion of metformin in diabetic patients with and without tuberculosis. Indian J Tuberc. 2023;70(1):37-41. doi:10.1016/j.ijtb.2022.03.004.
Shah I, Kumar Das S, Shetty NS, Kannan T, Ramachandran G, Kumar AH. Pharmacokinetics of isoniazid in children with tuberculosis-A comparative study at two doses. Pediatr Pulmonol. 2020;55(3):660-665. doi:10.1002/ppul.24624
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Routinely perform therapeutic drug monitoring (TDM) of anti-TB drugs for selective patients treated under National TB Elimination program.
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